Releasing and structural/mechanical properties of nano-particle/Punica granatum (Pomegranate) in poly(lactic-co-glycolic) acid/fibrin as nano-composite scaffold
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چکیده
منابع مشابه
Spontaneous Differentiation of Human Mesenchymal Stem Cells on Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold
INTRODUCTION Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA). Here, we investigated the osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs) in vitro and possible use for the repair of RA-affected joints. METHODS MSCs derived from hea...
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Introduction Osteo-chondral articular defects still represent a key concern in modern orthopaedic surgery and several techniques have been so far proposed (1). A novel strategy able to promote cartilage and sub-chondral bone regeneration of full-thickness defects was recently developed, consisting on implantation of a three-layered nano-composite biomimetic scaffold. This peculiar structure mim...
متن کاملHierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite.
A bone scaffold material (nano-HA/ collagen/PLA composite) was developed by biomimetic synthesis. It shows some features of natural bone both in main composition and hierarchical microstructure. Nano-hydroxyapatite and collagen assembled into mineralized fibril. The three-dimensional porous scaffold materials mimic the microstructure of cancellous bone. Cell culture and animal model tests showe...
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Mesenchymal stem cells (MSC) have been used recently for the treatment of autoimmune diseases in murine animal models due to the immunoregulatory capacity. Current utilization of MSC requires cells in certain quantity with multiple courses of administration, leading to limitation in clinical usage. Here we efficiently treated collagen-induced arthritis rats with a single local implantation with...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2021
ISSN: 1336-0345
DOI: 10.4149/bll_2021_007