Release of PLGA–encapsulated dexamethasone from microsphere loaded porous surfaces
نویسندگان
چکیده
منابع مشابه
Release of PLGA–encapsulated dexamethasone from microsphere loaded porous surfaces
The aim of the present study was to investigate the morphology and function of a drug eluting metallic porous surface produced by the immobilization of poly lactide-co-glycolide microspheres bearing dexamethasone onto plasma electrolytically oxidized Ti-6Al-7Nb medical alloy. Spheres of 20 microm diameter were produced by an oil-in-water emulsion/solvent evaporation method and thermally immobil...
متن کاملInvestigation of drug release from paclitaxel loaded polylactic acid nanofibers
Objective(s): In this study, drug loaded electrospun nanofibrous mats were prepared and drug release and mechanism from prepared nanofibers were investigated. Materials and Methods: Paclitaxel (PTX) loaded polylactic acid (PLA) nanofibers were prepared by electrospinning. The effects of process parameters, such as PTX concentration, tip to collector distance, voltage, temperature and flow rate...
متن کاملPorous microsphere and its applications
Porous microspheres have drawn great attention in the last two decades for their potential applications in many fields, such as carriers for drugs, absorption and desorption of substances, pulmonary drug delivery, and tissue regeneration. The application of porous microspheres has become a feasible way to address existing problems. In this essay, we give a brief introduction of the porous micro...
متن کاملControlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide
PURPOSE The current study aims to evaluate a porous silicon-based drug delivery system meant for sustained delivery of dexamethasone (Dex) to the vitreous and retina. METHODS Dexamethasone was grafted covalently into the pore walls of fully oxidized porous silicon particles (pSiO2-COO-Dex), which then was evaluated for the pharmacological effect of the payload on cultured ARPE19 cells before ...
متن کاملPorous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres.
In this study, ionic immobilization of dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres was performed on the hydroxyapatite (HAp) scaffold surfaces. It was hypothesized that in vivo bone regeneration could be enhanced with HAp scaffolds containing DEX-loaded PLGA microspheres compared to the use of HAp scaffolds alone. In vitro drug release from the encapsulated micr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Materials Science: Materials in Medicine
سال: 2009
ISSN: 0957-4530,1573-4838
DOI: 10.1007/s10856-009-3846-6