Release of Moxifloxacin From Corneal Collagen Shields
نویسندگان
چکیده
منابع مشابه
Collagen corneal shields.
Collagen corneal shields were developed as a corneal bandage lens and are currently indicated for ocular surface protection following surgery and in traumatic and nontraumatic corneal conditions. Collagen shields are manufactured from porcine or bovine collagen and three different collagen shields are currently available with dissolution times of 12, 24, and 72 hours. The theoretical, experimen...
متن کاملOxygen permeability of collagen shields.
The oxygen permeability (Dk) of ten 24-hr collagen shields was measured directly by polarographic methodology at approximately 2 hr of hydration. Edge and boundary effects were included in the calculations. Dk was found to be approximately 26 x 10(-11) cm ml O2/sec ml mmHg at 35 degrees C. Mean water content of the shields was 65.7% (SD = 1.0%) as measured by a hand refractometer. Therefore, th...
متن کاملThe effect of collagen shields on rabbit corneal reepithelialization after chemical debridement.
We evaluated the effect of precarved collagen lenses on the kinetics of epithelial wound healing in an experimental model of corneal erosions. After induction of anesthesia, central corneal erosions of 5-mm diameter were created in New Zealand white rabbits using n-heptanol. Animals were randomly assigned either to the treatment group or to one of three control groups. Each animal in the treatm...
متن کاملModeling of drug release from collagen matrices.
Drug release from collagen matrices is in most cases governed by diffusion from swollen matrices but also enzymatic matrix degradation or hydrophobic drug/collagen interactions may contribute. To reduce water uptake and to prolong the release, insoluble collagen matrices have been chemically or dehydrothermally crosslinked. Assuming Fickian diffusion a one-dimensional model was developed and te...
متن کاملCorneal Collagen Crosslinking Articles
1. Results of Collagen Crosslinking for Keratoconus ................................. 2 2. Patient Selection ................................................................................. 14 3. Patient Subjective Visual Function after Crosslinking ............................ 22 4. Corneal Shape and Topography Changes ............................................. 27 5. Higher Order Aberratio...
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ژورنال
عنوان ژورنال: Eye & Contact Lens: Science & Clinical Practice
سال: 2018
ISSN: 1542-2321
DOI: 10.1097/icl.0000000000000421