Release-Activated Ca2+ Transport in Neurons of Frog Sympathetic Ganglia

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Release-Activated Ca2+ Transport in Neurons of Frog Sympathetic Ganglia

Frog sympathetic ganglion neurons exhibit a novel Ca2+ uptake mechanism, release-activated calcium transport or RACT, which is manifest in both cytosolic and store [Ca2+] signals as greatly accelerated Ca2+ uptake after Ca2+ release from internal stores. RACT is activated by Ca2+ release but not by Ca2+ entry and serves to selectively refill Ca2+ stores after release. RACT lowers cytosolic [Ca2...

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In many neurons, Ca(2+) signaling depends on efflux of Ca(2+) from intracellular stores into the cytoplasm via caffeine-sensitive ryanodine receptors (RyRs) of the endoplasmic reticulum. We have used high-speed confocal microscopy to image depolarization- and caffeine-evoked increases in cytoplasmic Ca(2+) levels in individual cultured frog sympathetic neurons. Although caffeine-evoked Ca(2+) w...

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ژورنال

عنوان ژورنال: Neuron

سال: 1997

ISSN: 0896-6273

DOI: 10.1016/s0896-6273(00)80949-6