Relaxin family peptide receptors in GtoPdb v.2021.3

Relaxin family peptide receptors (RXFP, nomenclature as agreed by the NC-IUPHAR Subcommittee on [18, 81]) may be divided into two pairs, RXFP1/2 and RXFP3/4. Endogenous agonists at these are heterodimeric hormones structurally related to insulin: relaxin-1, relaxin, relaxin-3 (also known INSL7), insulin-like 3 (INSL3) INSL5. Species homologues of relaxin have distinct pharmacology interacts with RXFP1, RXFP2 RXFP3, whereas mouse rat selectively bind activate RXFP1 [184]. is ligand for RXFP3 but it also binds RXFP4 has differential affinity between species [183]. INSL5 a weak antagonist RXFP3. INSL3 multiple complex binding interactions [189] [91] which direct N-terminal LDLa modules together linker domain act tethered receptor signaling [186]. interact their using residues in B-chains binding, activation, respectively [225, 104].