RELAX: Detecting Relaxed Selection in a Phylogenetic Framework
نویسندگان
چکیده
منابع مشابه
Phylogenetic Window Analysis for Detecting Chronological Changes in Natural Selection
Natural selection operating at the amino acid sequence level can be detected by comparing the rates of synonymous (rS) and nonsynonymous (rN) substitutions for the protein-coding nucleotide sequence, where relationships rN > rS and rN < rS conventionally indicate positive and negative selection, respectively. The direction and magnitude of natural selection operating on a protein may change dur...
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RIFO, as has been proposed by Nebel et al. (Nebel, Dimopoulos, and Koehler 1997), is a method that can automatically detect irrelevant information in planning tasks. The idea is to remove such irrelevant information as a pre-process to planning. While RIFO has been shown to be useful in a number of domains, its main disadvantage is that it is not completeness preserving. Furthermore, the pre-pr...
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Natural populations often experience the weakening or removal of a source of selection that had been important in the maintenance of one or more traits. Here we refer to these situations as 'relaxed selection,' and review recent studies that explore the effects of such changes on traits in their ecological contexts. In a few systems, such as the loss of armor in stickleback, the genetic, develo...
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Humans have colonized the planet through a series of range expansions, which deeply impacted genetic diversity in newly settled areas and potentially increased the frequency of deleterious mutations on expanding wave fronts. To test this prediction, we studied the genomic diversity of French Canadians who colonized Quebec in the 17th century. We used historical information and records from ∼400...
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Understanding the processes that give rise to quantitative measurements associated with molecular sequence data remains an important issue in statistical phylogenetics. Examples of such measurements include geographic coordinates in the context of phylogeography and phenotypic traits in the context of comparative studies. A popular approach is to model the evolution of continuously varying trai...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2014
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msu400