Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation
نویسندگان
چکیده
منابع مشابه
Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation.
The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance. Responsible T cell clones could be activated through the direct and indirect pathways of allorecognition. We examined the role of the indirect pathway in liver...
متن کاملEthylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance.
Strategic exposure to donor Ags prior to transplantation can be an effective way for inducting donor-specific tolerance in allogeneic recipients. We have recently shown that pretransplant infusion of donor splenocytes treated with the chemical cross-linker ethylenecarbodiimide (ECDI-SPs) induces indefinite islet allograft survival in a full MHC-mismatched model without the need for any immunosu...
متن کاملLangerhans cells, orthotopic corneal allografts, and direct and indirect pathways of T-cell allorecognition.
PURPOSE To determine after orthotopic corneal allografting the role of Langerhans cells in activation of T cells via the direct and indirect pathways of allorecognition and the relationship between these pathways and the rapidity of graft rejection. METHODS Corneas from eyes of normal mice and from eyes after superficial cauterization were grafted to eyes of major histocompatibility complex (...
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Advances in immunosuppressive therapy have greatly impacted on the successful outcome of organ –and most particularly liver– transplantation. With the introduction of new immunosuppressants the incidence of acute rejection has considerably decreased, and transplanted patient survival is now 83% and 70% after 1 and 5 years, respectively (1). However, toxicity associated with these drugs is signi...
متن کاملWhat Is Direct Allorecognition?
Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived 'passenger' dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct al...
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ژورنال
عنوان ژورنال: Liver Transplantation
سال: 2008
ISSN: 1527-6465,1527-6473
DOI: 10.1002/lt.21378