Relative chloroquine resistance.

Chloroquine resistance in malaria.

Malaria continues to pose a challenge in view of its resurgence and problem of drug resistance. The chloroquine resistance in P. falciparum was first detected in Thailand in 1962(1) and in India in 1973(2). The extent of problem of chloroquine resistance in P. falciparum is increasing every year. Chloroquine resistance in P. falciparum has already been found in twelve different states and Union...

Malaria: Dissecting chloroquine resistance

The malaria parasite's development of resistance to the drug chloroquine is a major threat to world health. A protein likely to be involved in chloroquine resistance has recently been identified; this discovery is important, but raises as many questions as it answers.

Chloroquine resistance in Plasmodium vivax.

Chloroquine resistance in malaria: a deficiency of chloroquine binding.

Chloroquine-(14)C was used to study the processes which concentrate chloroquine in mouse red blood cells infected with chloroquine-sensitive or with chloroquine-resistant Plasmodium berghei. The initial rates of uptake and exchange of chloroquine-(14)C were both too fast to measure, yet large concentration gradients were maintained by the cells. When red blood cells were exposed to 10(-8)M chlo...

Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei

Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent Plasmodia. Using animal Plasmodia, particularly primate and rodent Plasmodia can be useful model for human Plasmodia studies. In this study we have tried to consider and compare the sequence of ...