Relationships Between Perivascular Adipose Tissue and Abdominal Aortic Aneurysms
نویسندگان
چکیده
منابع مشابه
Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms.
BACKGROUND Abdominal aortic aneurysm (AAA) is a deadly irreversible weakening and distension of the abdominal aortic wall. The pathogenesis of AAA remains poorly understood. Investigation into the physical and molecular characteristics of perivascular adipose tissue (PVAT) adjacent to AAA has not been done before and is the purpose of this study. METHODS AND RESULTS Human aortae, periaortic P...
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Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by aortic dilation and rupture leading to sudden death. Currently, no non-surgical treatments are available and novel therapeutic targets are needed to prevent AAA. We investigated whether increasing plasma levels of adiponectin (APN), a pleiotropic adipokine, provides therapeutic benefit to prevent AngII-induced advanced A...
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The contribution of abdominal aortic aneurysm (AAA) disease to human morbidity and mortality has increased in the aging, industrialized world. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of the diseased aorta. This work aims to develop novel diagnostic and therapeutic strategies to limit AAA expansion and, ultimately, r...
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This article is a Directed Reading. Your access to Directed Reading quizzes for continuing education credit is determined by your membership status and CE preference. The aorta is the largest artery in the human body. Originating from the left ventricle, it extends into the chest and down into the abdomen. The vessel is the main conduit for distributing oxygenated blood from the heart to the bo...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2021
ISSN: 1664-2392
DOI: 10.3389/fendo.2021.704845