Relationships between DNA repair and RTK-mediated signaling pathways

Receptor Tyrosine Kinases (RTK) are an important family involved in numerous signaling pathways essential for proliferation, cell survival, transcription or cell-cycle regulation. Their role and involvement cancer survival have been widely described the literature, generally associated with overexpression and/or excessive activity pathology. Because of these characteristics, RTKs relevant targets fight against cancer. In last decade, increasingly works describe RTK modulation DNA repair, thus providing evidence relationship between protein actors repair pathways. this review, we propose a summary as potential modulators double-stranded order to put forward new lines research aimed at implementation therapeutic strategies targeting both RTK-mediated