Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process

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Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process.

The levels of the five methylated nucleosides pseudouridine (psi-Urd), 1-methyladenosine (1-MeAdo), 4 acetylcytidine (4-AcCyd), 1 methylinosine (1-Melno) and 7 methylguanosine (7-MeGuo) resulting from RNA degradation were examined in the urine of rheumatoid arthritis (RA) patients. Of these five, 1-MeAdo and psi-Urd were correlated with the active phase of the disease, while two others (4-AcCyd...

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Transfer RNA is the most complex biomacromolecule in both structure and function. The complexity of its structure is caused by a large variety of enzymes which add modifying groups to the four bases after the primary synthesis. The most abundant of these enzymes are the transfer RNA methylases, which add methyl groups at various positions in the macromolecule. These methylating enzymes were fou...

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URINARY 6b-HYDROXYCORTISOL EXCRETION IN RHEUMATOID ARTHRITIS

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ژورنال

عنوان ژورنال: Rheumatology

سال: 1997

ISSN: 1462-0324,1462-0332

DOI: 10.1093/rheumatology/36.9.990