Relationship Between PNPLA3 rs738409 Polymorphism and Decreased Kidney Function in Children With NAFLD
نویسندگان
چکیده
منابع مشابه
A New PCR-RFLP Method for Diagnosing PNPLA3 rs738409 Polymorphism
Article ID: WMC002401 Article Type: Research Protocol Submitted on:01-Nov-2011, 12:31:07 PM GMT Published on: 02-Nov-2011, 05:42:47 PM GMT Article URL: http://www.webmedcentral.com/article_view/2401 Subject Categories:GENETICS
متن کاملAssociation of rs738409 Polymorphism in the PNPLA3 Gene with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated incidence of 20%–30% in the general population and 67%–75% in the obese population. Genetic predisposition can play an important role in development of this disease. Nonsynonymous coding SNP rs738409 C/G (I148Met) in the PNPLA3 gene has been found to be associated with the presence of...
متن کاملPNPLA3 and TNF-α G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD
Introduction: There is growing evidence that genetic and environmental factors play an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). We investigated the association of single nucleotide polymorphism (SNP) rs738409 in PNPLA3 gene and TNF-α G238A polymorphism with the development and severity of NAFLD in an overweight and obese Egyptian population...
متن کاملInfluence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects
In normal weight subjects (body mass index < 25 kg/m2), non-alcoholic fatty liver disease (NAFLD) is likely to coexist with metabolic diseases. The patatin-like phospholipase 3 (PNPLA3) polymorphism rs738409 (c.444C>G) is associated with the risk of NAFLD and/or renal dysfunction; however, the influence of the weight status on the associations remains unknown. We aimed to clarify the associatio...
متن کاملAssociation between patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphism and overweight/obesity: a meta-analysis
Background: The patatin-like phospholipase domain-containing 3 (PNPLA3, rs738409) gene polymorphism has been implicated in susceptibility to overweight and obesity, but study results are still controversial. Objective: The present meta-analysis was performed to evaluate the relationship between PNPLA3 polymorphism and overweight/obesity among adults, children or adolescents. Methods: A literatu...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2019
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.30625