Relationship between cytokine mRNA expression and organ damage following cecal ligation and puncture
نویسندگان
چکیده
منابع مشابه
Cecal ligation puncture procedure.
Human sepsis is characterized by a set of systemic reactions in response to intensive and massive infection that failed to be locally contained by the host. Currently, sepsis ranks among the top ten causes of mortality in the USA intensive care units. During sepsis there are two established haemodynamic phases that may overlap. The initial phase (hyperdynamic) is defined as a massive production...
متن کاملCecal ligation and puncture induced sepsis
Purpose: Multiresistant and vancomycin resistant Enterococcus faecium (VRE) can cause serious infections in hospitalized patients with various co-morbid diseases. We investigated the course of VRE peritonitis after cecal ligation and puncture (CLP)-induced sepsis and compared this to sham operated mice. Methods: Mice were subjected to CLP or sham surgery. Forty-eight hours thereafter four group...
متن کاملA New Approach to Monitoring and Evaluation of Cecal Ligation and Puncture Sepsis Model
Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...
متن کاملMortality and bacteriology of sepsis following cecal ligation and puncture in aged mice.
Epidemiologic data suggest that elderly adults are more susceptible to invasive bacterial infection by indigenous gut flora than are younger adults. The purpose of this investigation was to characterize a murine model of clinically encountered peritonitis in the aged. We subjected three different age groups (young, 16 weeks; mature, 12 months; senescent, 24 months) of C57BL/6NNia mice to surgic...
متن کاملVolatile anesthetics improve survival after cecal ligation and puncture.
BACKGROUND Sepsis remains a leading cause of death in intensive care units. There is growing evidence that volatile anesthetics have beneficial immunomodulatory effects on complex inflammation-mediated conditions. The authors investigated the effect of volatile anesthetics on the overall survival of mice in a sepsis model of cecal ligation and puncture (CLP). METHODS Mice (N = 12 per treatmen...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2002
ISSN: 1007-9327
DOI: 10.3748/wjg.v8.i1.131