Relationship between C-reactive protein and periodontal disease: A new tale of an old molecule

Oral fluids are a substrate for new generation of non-invasive diagnostic tools through the development of ultra- and high-sensitive detection systems fact that they contain many serum analytes reflect normal function or disease status.Within oral cavity C-reactive protein (CRP) has been detected in both gingival crevicular fluid (GCF) saliva, is considered to be an important biomarker systemic disease.We review biological properties CRP, association between CRP periodontal disease, and possibility may potent therapeutic target. A systematic search data related to the was performed recognize studies on animals and human (PUBMED, MEDLINE, COCHRANE, Google search). Keywords: Acute phase reactants, Creactive protein, Cardiovascular disease, Periodontal disease.