Relationship between bispectral index and effect-site EC50 for propofol
نویسندگان
چکیده
منابع مشابه
Relationship between bispectral index, auditory evoked potential index and effect-site EC50 for propofol at two clinical end-points.
BACKGROUND Many anaesthetists are deterred from using total i.v. anaesthesia because of uncertainty over the concentration of propofol required to prevent awareness. We predicted blood and effect-site concentrations of propofol at two clinical end-points: loss of consciousness and no response to a painful stimulus. METHODS Forty unpremedicated Caucasian patients were anaesthetized with i.v. p...
متن کاملEffect of remifentanil on plasma propofol concentration and bispectral index during propofol anaesthesia.
BACKGROUND Propofol and remifentanil are commonly administered together in clinical anaesthesia, but the effect of remifentanil on the plasma concentration of propofol has yet to be established. The aim of the present study was to investigate the effect of remifentanil on plasma propofol concentrations (Cp) in the absence of surgical stimulation. METHODS Thirty-eight patients undergoing elect...
متن کاملCorrelation between Bispectral Index and Predicted Effect-site Concentration of Propofol in Different Levels of Target-Controlled, Propofol Induced Sedation in Healthy Volunteers
Introduction: Bispectral Index is an objective tool to assess electroencephalographic activity and measure the effect of certain sedatives and hypnotics on the brain. In addition, there are certain subjective tools such as the observer's assessment of alertness and sedation which are used. The correlation between BIS and the concentration of propofol in the brain, and the relationship between t...
متن کاملA comparison between bispectral index analysis and auditory-evoked potentials for monitoring the time to peak effect to calculate the plasma effect site equilibration rate constant of propofol.
BACKGROUND AND OBJECTIVES To the best of our knowledge, the value of the plasma effect site equilibration rate constant (k(e0)) of propofol has not been reported in Chinese patients. The aim of this prospective, randomized study was to examine the characteristics of the time to peak effect (T(PEAK)) of propofol, a pharmacokinetic-independent descriptor of blood-brain equilibration, and k(e0) de...
متن کاملBispectral index monitoring during sedation with sevoflurane, midazolam, and propofol.
BACKGROUND Bispectral Index (BIS) has been used to measure sedation depth. Ideally, to guide anesthetic management, range of BIS scores at different sedation levels should not overlap, and BIS should be independent of drug used. This study assessed ability of BIS to predict sedation depth between sevoflurane, propofol, and midazolam. Quality of recovery was also compared. METHODS Patients und...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2006
ISSN: 0007-0912,1471-6771
DOI: 10.1093/bja/aei635