Relationship between auditory thresholds, central spontaneous activity, and hair cell loss after acoustic trauma
نویسندگان
چکیده
منابع مشابه
Relationship between hair cell loss on the chick basilar papilla and threshold shift after acoustic overstimulation.
Three groups of chickens were continuously exposed to 125dB SPL pure tones at either 500, 1500 or 3000 Hz for 12 h. Ten days after the exposure to noise, a good correlation was found between the percentage of hair cell loss and the threshold shifts of the eighth nerve action potential. The data suggest possible roles for the two types’ of hair cells present on the basilar papilla. In addition i...
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Introduction: Electrically evoked compound action potential (ECAP) is an objective auditory response that can be used in the programing of cochlear implants. The aims of this study were to monitor ECAP thresholds and auditory, language and speech progress for 6 months after cochlear implant surgery and to evaluate any relationship between them. Materials and Methods: Ten children with a m...
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BACKGROUND Exposure to intense sound or high doses of aminoglycoside antibiotics can increase hearing thresholds, induce cochlear dysfunction, disrupt hair cell morphology and promote hair cell death, leading to permanent hearing loss. When the two insults are combined, synergistic ototoxicity occurs, exacerbating cochlear vulnerability to sound exposure. The underlying mechanism of this synerg...
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Hearing loss can be caused by a variety of insults, including acoustic trauma and exposure to ototoxins, that principally effect the viability of sensory hair cells via the MAP kinase (MAPK) cell death signaling pathway that incorporates c-Jun N-terminal kinase (JNK). We evaluated the otoprotective efficacy of D-JNKI-1, a cell permeable peptide that blocks the MAPK-JNK signal pathway. The exper...
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ژورنال
عنوان ژورنال: The Journal of Comparative Neurology
سال: 2011
ISSN: 0021-9967
DOI: 10.1002/cne.22644