Relationship Between Aminoglycoside-Induced Nephrotoxicity and Auditory Toxicity
نویسندگان
چکیده
منابع مشابه
Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans.
We analyzed data from three prospective, controlled, randomized, double-blind clinical trails to determine whether furosemide increases the nephrotoxicity and auditory toxicity of aminoglycosides. All patients who received at least 72 h of treatment and who had no other cause for nephrotoxicity or auditory toxicity were included in the analysis. Nephrotoxicity developed in 10 of 50 (20.0%) pati...
متن کاملAminoglycoside nephrotoxicity
Aminoglycoside are frequently used due to its high efficacy against gram-negative bacteria and positive synergism with other antibiotics against gram-positive organisms. They are commonly used for prevention and treatment of infection complications after cardiothoracic surgery. The principal side effect of this class of antibiotics is nephrotoxicity, which may occur in up to 20% of the exposed ...
متن کاملMorphological methods to evaluate protective agents against aminoglycoside-induced nephrotoxicity
*Corresponding author: Sandra Rodríguez Salgueiro, Electron Microscopy Laboratory, National Center for Scientific Research, Cubanacán, Havana, Cuba. E-mail: [email protected] Aminoglycosides are a family of antibiotics widely used in clinical practice. Their prescription is restricted by cytotoxicity and accumulation of antibiotic in renal tissues (1). Although renal damage induced b...
متن کاملAminoglycoside nephrotoxicity: modeling, simulation, and control.
The main constraints on the administration of aminoglycosides are the risks of nephrotoxicity and ototoxicity, which can lead to acute, renal, vestibular, and auditory toxicities. In the present study we focused on nephrotoxicity. No reliable predictor of nephrotoxicity has been found to date. We have developed a deterministic model which describes the pharmacokinetic behavior of aminoglycoside...
متن کاملTitle : Aminoglycoside Nephrotoxicity: Modeling, Simulation and Control
Address: (1) ADCAPT, Service Pharmaceutique, Hôpital Antoine Charial, Francheville, France. (2) Université Paris−Sud, Laboratoire des Signaux et Systèmes (CNRS−SUPELEC), Gif−sur− Yvette, France. (3) INRETS, Bron, France. (4) Laboratoire GAGE, Ecole Polytechnique, Palaiseau, France. (5) Laboratory of Applied Pharmacokinetics, University of Southern California, School of Medicine, Los Angeles CA ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1979
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.15.6.780