Relapses and disability accumulation in progressive multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Modifiable factors influencing relapses and disability in multiple sclerosis.
A growing body of literature indicates that the natural course of multiple sclerosis can be influenced by a number of factors. Strong evidence suggests that relapses can be triggered by infections, the postpartum period and stressful life events. Vaccinations against influenza, hepatitis B and tetanus appear to be safe. Surgery, general and epidural anaesthesia, and physical trauma are not asso...
متن کاملAge and disability accumulation in multiple sclerosis.
OBJECTIVES We tested the hypothesis that age is a prognostic factor with respect to long-term accumulation of disability in multiple sclerosis (MS). METHODS Kaplan-Meier analysis and binary logistic regression models determined the effect of age at disease onset, age at onset of progression, and current age on attainment of severe disability levels (Disability Status Scale [DSS] 6-8-10) from ...
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Background: Identifying the predictors of pain is important for both health professionals and researchers, because pain has repeatedly been found to be a strong predictor of activity limitations and participation restrictions. The objective of this study was to determine the predictors of pain presence and severity in a large, well-designed sample of community dwelling individuals with multip...
متن کاملModifying disability in progressive multiple sclerosis
www.thelancet.com Vol 383 June 28, 2014 2189 Multiple sclerosis is the most common cause of chronic neurological disability in young adults in developed countries and seems to be increasing in frequency. Disease presentation in 80–90% of patients follows an initial phase characterised by bouts of relapsingremitting neurological dysfunction. These relapses are thought to represent focal areas of...
متن کاملCortical relapses in multiple sclerosis.
BACKGROUND Multiple sclerosis (MS) is a white and grey matter disease of the central nervous system (CNS). It is recognized that cortical damage (i.e. focal lesions and atrophy) plays a role in determining the accumulation of physical and cognitive disability that is observed in patients with progressive MS. To date, an association of cortical lesions with clinical relapses has not been describ...
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ژورنال
عنوان ژورنال: Neurology
سال: 2014
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000001094