Reinitiation of compensatory lung growth after subsequent lung resection
نویسندگان
چکیده
منابع مشابه
Compensatory Lung Growth After Pneumonectomy
Pneumonectomy, the surgical removal of a lung, elicits a number of anatomical changes within the thoracic cavity that augments the diffusion capacity of the remaining lung. Pneumonectomy directs the entire cardiac output into the remaining lung and creates an empty hemithorax that results in a shift of the mediastinum toward the vacated thoracic compartment. In a number of experimental animal m...
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Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmon...
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Growth of the lung involves unique structure-function interactions not seen in solid organs. Mechanical feedback between the lung and thorax constitutes a major signal that sustains developmental as well as compensatory lung growth. After the loss of lung units as by pneumonectomy (PNX), increased mechanical stress and strain on the remaining units induce adaptive responses to augment oxygen tr...
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In small mammals, partial pneumonectomy (PNX) elicits rapid hyperplastic compensatory growth of the remaining lung parenchyma to restore normal lung mass, structure, and function. In BALB mice subjected to PNX, compensatory lung growth is complete within 10 days. Because cellular hyperplasia contributes to the mechanism of tumor promotion by butylated hydroxytoluene (BHT), we hypothesized that ...
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135 Received June 1, 2012; accepted September 3, 2012. Published online September 14, 2012; doi: 10.1620/tjem.228.135. Correspondence: Sumiko Maeda, M.D., Ph.D., Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiryomachi, Aobaku, Sendai, Miyagi 980-8575, Japan. e-mail: [email protected] *Present address: Department of Thoracic Surgery, Tohoku University Hospital, 4-1 Seiry...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2007
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2007.07.005