REIGNY, Dossier documentaire (1369-1371)

NpgRj_Ng_1685 1367..1371

The structure of a protein depends critically on the complex interactions among its amino acid residues. It has long been hypothesized that interacting residues might tend to coevolve, but it is not known whether such coevolution is a general phenomenon across the proteome. Here, we describe a novel methodology called phylogeny-aided structural analysis, which uncovers robust signals of interac...

Op-brai130031 1371..1382

1 Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan 2 Stroke Centre, Aichi Medical University, Aichi 480-1195, Japan 3 Laboratory for Motor Neuron Disease, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan 4 CREST, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan 5 Department of Neurology, Kyoto Univer...

Relations sémantiques pour l'ingénierie documentaire

The growing part of the New Technologies of Information and Communication (NTIC) comes along with the passage on numeric support of many documentary capitals. So, we attend gradually the digitalization of working documents of all kinds: medical files, educational files, technical documentations, etc. But how make sure that this change of paradigm benefits the readers and the authors of document...

Dmd062745 1360..1371

Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6cyclin D1-Rb-p16/ink4a pathway using a potent CDK4 and CDK6 kinase inhibitor has potential for treating primary central nervous system tumors such as glioblastoma and some peripheral tumors with high incidence of brain metastases. We compared central nervous system exp...

Dossier – Mineral oil hydrocarbons