Regulatory T Cell Differentiation: Turning Harmful into Useful
نویسندگان
چکیده
منابع مشابه
Transcriptional control of regulatory T-cell differentiation.
Regulatory T (Treg) cells are essential for maintaining peripheral tolerance and for limiting excessive inflammatory responses under various conditions. The lineage-specific transcription factor Foxp3 has a critical role in Treg-cell biology. Foxp3 forms large protein complexes and cooperates with environmentally induced transcription factors to shape the Treg-cell transcriptional program. Here...
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The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood. Here, we found that Stat3 is indispensibl...
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ژورنال
عنوان ژورنال: Immunity
سال: 2012
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2012.09.002