Regulatory science for antiplatelet therapies
نویسندگان
چکیده
منابع مشابه
Scavenger receptors: targets for antiplatelet therapies?
P latelets play a critical role in thrombotic diseases such as myocardial infarction or ischemic stroke. Beyond their role in thrombosis, platelets are the major trigger in boosting atherosclerosis.2 In patients with hypercholesterolemia, platelets are hyperreactive, indicating that circulating lipoproteins in blood influence platelet properties. Lipidlowering drugs result in a reduction of pla...
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T hrombin is a key stimulus for fibrin generation as well as a potent platelet activator through interaction with protease-activated receptors on the platelet surface. Vorapaxar is a reversible and selective inhibitor of the PAR-1 receptor, the major thrombin receptor on platelets, and has been evaluated in 2 large clinical trials. A total of 12 944 patients with non–ST elevation acute coronary...
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Cognitive regulatory control processes play an essential but typically unap-preciated role in maintaining mental health. The purpose of the current paper is to identify this role and demonstrate how cognitive-behavioral and related techniques can compensate for impairments. Impaired cognitive regulation contributes to the overly intense emotional states present in anxiety disorders , depression...
متن کاملNewly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies
OBJECTIVE Aspirin together with thienopyridine P2Y12 inhibitors, commonly clopidogrel, is a cornerstone of antiplatelet therapy. However, many patients receiving this therapy display high on-treatment platelet reactivity, which is a major therapeutic hurdle to the prevention of recurrent thrombotic events. The emergence of uninhibited platelets after thrombopoiesis has been proposed as a contri...
متن کاملBalancing Antiplatelet and Anticoagulant Therapies in Patients with Cardiovascular Disease
Anticoagulation is needed for stroke prevention in patients with atrial fibrillation. Antiplatelet therapy is essential for the prevention of stent thrombosis and the reduction of cardiovascular events in patients who undergo coronary stenting and suffer acute coronary syndromes. When these conditions overlap, the individual antithrombotic strategies are commonly combined, and the efficacy bene...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2013
ISSN: 0915-7441,1880-8808
DOI: 10.2491/jjsth.24.269