Regulatory Role for Krüppel-Like Zinc-Finger Protein Gli-Similar 1 (Glis1) in PMA-Treated and Psoriatic Epidermis
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منابع مشابه
Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1)
Glis2 is a member of the Gli-similar (Glis) subfamily of Krüppel-like zinc finger transcription factors. It functions as an activator and repressor of gene transcription. To identify potential co-activators or co-repressors that mediate these actions of Glis2, we performed yeast two-hybrid analysis using Glis2 as bait. C-terminal binding protein 1 (CtBP1) was identified as one of the proteins t...
متن کاملModulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.
Glis3 is a member of the Glis subfamily of Krüppel-like zinc finger transcription factors. Recently, Glis3 has been linked to both type I and type II diabetes and shown to positively regulate insulin gene expression. In this study, we have identified a region within the N terminus of Glis3 that shares high levels of homology with the Cubitus interruptus (Ci)/Gli family of proteins. We demonstra...
متن کاملThe Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription
Glis3 is a member of the Krüppel-like family of transcription factors and is highly expressed in islet beta cells. Mutations in GLIS3 cause the syndrome of neonatal diabetes and congenital hypothyroidism (NDH). Our aim was to examine the role of Glis3 in beta cells, specifically with regard to regulation of insulin gene transcription. We demonstrate that insulin 2 (Ins2) mRNA expression in rat ...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology GLI 2 ( GLI family zinc finger 2 )
Description Protein: Human GLI2 was originally identified as a Tax-helper protein (THP) that binds to Tax-responsive element in the long terminal repeat of the human T-cell leukemia virus (Tanimura et al., 1998). However, when compared to orthologous GLI2 genes from different species, the human mRNAs lacked a part of the 5' region encoding the evolutionarily conserved Nterminus of GLI2. Roessle...
متن کاملCloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors.
We have identified a novel zinc finger protein that has been named ubiquitous Krüppel-like factor (UKLF) based on structural considerations and the pattern of gene expression. UKLF was isolated by the polymerase chain reaction approach using degenerate oligonucleotides corresponding to the DNA-binding domain of erythroid Krüppel-like factor (EKLF) and cDNA prepared from human vascular endotheli...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2006
ISSN: 0022-202X
DOI: 10.1038/sj.jid.5700018