منابع مشابه
tRNA: Vast reservoir of RNA molecules with unexpected regulatory function.
T ransfer RNA (tRNA) is a ubiquitous class of housekeeping RNA required for reading the genetic code in protein synthesis. The involvement of tRNA in translation begins with the transfer of amino acids onto cognate tRNA catalyzed by specific aminoacyl-tRNA synthetases. AminoacyltRNAs are then shuttled to the ribosome by elongation factors, where the amino acid is incorporated into the new polyp...
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Advances in both experimental and computational approaches to genome-wide analysis of RNA transcripts have dramatically expanded our understanding of the ubiquitous and diverse roles of regulatory non-coding RNAs. This conference session includes presentations exploring computational approaches for detecting regulatory RNAs in RNA-Seq data, for analyzing in vivo CLIP data on RNA-protein interac...
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Ribonucleic acid (RNA) in its many facets of structure and function is becoming more fully understood, and, therefore, it is possible to design and use RNAs as valuable tools in molecular biology and medicine. Understanding of the role of RNAs within the cell has changed dramatically during the past few years. Therapeutic strategies based on non-coding regulatory RNAs include RNA interference (...
متن کاملTargeting RNA with small molecules.
5.1. Binding Sites of the Aminoglycosides 1185 5.2. Importance of Electrostatic Interactions 1185 5.3. Nonionic Interactions 1185 5.4. Pseudo-Base Pair Interactions 1186 5.5. Water-Mediated Contacts 1186 5.6. Shape Complementarity and Conformational Adaptation 1186 6. Assays for Evaluating RNA Binding 1186 6.1. Methods Utilizing Fluorescently Labeled RNA 1186 6.2. NMR-Based Methods 1187 6.3. El...
متن کاملMelting of branched RNA molecules.
In this Letter we show that the melting thermodynamics of RNA molecules is very sensitive to the branching geometry. We find that, when pairing interactions are described by a Gō model, unbranched RNA molecules with a linear geometry melt via a conventional continuous phase transition with classical exponents while RNA molecules with the branching geometry of a Cayley tree, with coordination nu...
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ژورنال
عنوان ژورنال: Microbiology Australia
سال: 2006
ISSN: 1324-4272
DOI: 10.1071/ma06124