منابع مشابه
Finding Regulatory Motifs
The most efficient step for gene regulation is transcription, i.e., the copy of DNA of a gene to mRNA molecule that ultimately is translated to a protein. Transcription is controlled in the promoter by a set of transcription factor binding sites (TFBSs). These TFBSs recruit transcription factors (TFs) that facilitates the allocation of the transcription machinery and, therefore, increase the pr...
متن کاملModeling regulatory motifs
Biological processes are mediated by specific interactions between cellular molecules (DNA, RNA, proteins, etc.). The molecular identification mark, or signature, required for precise and specific interactions between various biomolecules is not always clear, a comprehensive knowledge of which is critical not only for a mechanistic understanding of these interactions but also for therapeutic in...
متن کاملChaotic Motifs in Gene Regulatory Networks
Chaos should occur often in gene regulatory networks (GRNs) which have been widely described by nonlinear coupled ordinary differential equations, if their dimensions are no less than 3. It is therefore puzzling that chaos has never been reported in GRNs in nature and is also extremely rare in models of GRNs. On the other hand, the topic of motifs has attracted great attention in studying biolo...
متن کاملFinding regulatory elements and regulatory motifs: a general probabilistic framework
Over the last two decades a large number of algorithms has been developed for regulatory motif finding. Here we show how many of these algorithms, especially those that model binding specificities of regulatory factors with position specific weight matrices (WMs), naturally arise within a general Bayesian probabilistic framework. We discuss how WMs are constructed from sets of regulatory sites,...
متن کاملFunctional Characterization of Variations on Regulatory Motifs
Transcription factors (TFs) regulate gene expression through specific interactions with short promoter elements. The same regulatory protein may recognize a variety of related sequences. Moreover, once they are detected it is hard to predict whether highly similar sequence motifs will be recognized by the same TF and regulate similar gene expression patterns, or serve as binding sites for disti...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2013
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.23881