Regulation of transcription by 6S RNAs

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

down regulation of dhfr promoter activity by pml transcription repressor

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Gene regulation by small RNAs

The 5 annual international RNAi conference at Oxford, RNAi2010: Gene Regulation by Small RNAs, was held at St Hilda’s College, Oxford, UK (17-18 March). The meeting brought together experts from industry and academia and served as a forum to discuss new technological developments and interesting findings in the RNAi field. Research posters were displayed throughout the conference. Key sponsors ...

6S RNA regulation of pspF transcription leads to altered cell survival at high pH.

6S RNA is a highly abundant small RNA that regulates transcription through direct interaction with RNA polymerase. Here we show that 6S RNA directly inhibits transcription of pspF, which subsequently leads to inhibition of pspABCDE and pspG expression. Cells without 6S RNA are able to survive at elevated pH better than wild-type cells due to loss of 6S RNA-regulation of pspF. This 6S RNA-depend...

A transcription switch toggled by noncoding RNAs.

L ife is really getting complicated in the world of eukaryotic transcription. In the good old days, we were comfortable in the belief that transcription occurred primarily across the coding region of a gene, producing an mRNA for translation. However, over the past few years, this view has been turned topsy-turvy. Improved microarray and sequencing technologies have revealed that our picture of...