Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
نویسندگان
چکیده
منابع مشابه
Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B.
Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infe...
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PURPOSE To investigate the importance of Toll-like receptor 4 (TLR4) expression on hepatocytes obtained from Chronic Hepatitis B patients as well as on hepatocellular carcinoma HepG2 and HepG2.2.15 cell lines. METHODS Expression of TLR4 in liver tissues was determined by immunohistochemistry in 75 patients with CHB and in10 healthy controls. The protein and mRNA 1eve1s of TLR4 in hepatocellul...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2006
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.21482