Regulation of Lysophosphatidic Acid Metabolism and Signaling by Lipoproteins

Regulation of angiogenesis by phospholipid lysophosphatidic acid.

Lysophosphatidic acid (LPA) as a bioactive phospholipid signaling mediator is emerging as an important regulator of endothelial cell functions and angiogenesis. Many studies have shown that LPA is an active player in regulating the processes of endothelial cell migration, proliferation, and differentiation, all essential in angiogenesis. Through modulating angiogenesis associated gene expressio...

Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling.

In peripheral nerves, Schwann cells (SCs) form contacts with axons, other SCs, and extracellular matrix components that are critical for their migration, differentiation, and response to injury. Here, we report that lysophosphatidic acid (LPA), an extracellular signaling phospholipid, regulates the morphology and adhesion of cultured SCs. Treatment with LPA induces f-actin rearrangements result...

Lysophosphatidic acid in neural signaling.

The physiological and pathological importance of lysophosphatidic acid (LPA) in the nervous system is underscored by its presence, as well as the expression of its receptors in neural tissues. In fact, LPA produces responses in a broad range of cell types related to the function of the nervous system. These cell types include neural cell lines, neural progenitors, primary neurons, oligodendrocy...

Regulation of the pulmonary vasculature by lysophospholipase D autotaxin - lysophosphatidic acid signaling

Hsin-Yuan Cheng: Regulation of the pulmonary vasculature by lysophospholipase D autotaxin-lysophosphatidic acid signaling (Under the direction of Dr. Susan S. Smyth) Lysophosphatidic acid (LPA) is a bioactive lipid molecule present at physiologically relevant levels in serum that acts by binding to a family of G-protein coupled receptors. Receptor active LPA is produced by the plasma lysophosph...

Regulation of Stem Cell Differentiation into Cardiomyocytes by Lysophosphatidic Acid