Regulation of Hemostasis and Thrombosis
نویسندگان
چکیده
منابع مشابه
THROMBOSIS AND HEMOSTASIS Regulation of fibrinogen production by microRNAs
Elevated levels of fibrinogen are associated with increased risk of cardiovascular disease, whereas low fibrinogen can lead to a bleeding disorder. We investigated whether microRNAs (miRNAs), known to act as post-transcriptional regulators of gene expression, regulate fibrinogen production. Using transfection of a library of 470 annotated human miRNA precursor molecules in HuH7 hepatoma cells a...
متن کاملTHROMBOSIS AND HEMOSTASIS Regulation of fibrinolysis by S100A10 in vivo
Endothelial cells form the inner lining of vascular networks and maintain blood fluidity by inhibiting blood coagulation and promoting blood clot dissolution (fibrinolysis). Plasmin, the primary fibrinolytic enzyme, is generated by the cleavage of the plasma protein, plasminogen, by its activator, tissue plasminogen activator. This reaction is regulated by plasminogen receptors at the surface o...
متن کاملBrain regulation of thrombosis and hemostasis: from theory to practice.
T hrombosis and hemostasis impact stroke neurology and cerebrovascular disease. Decision making for stroke prevention and stroke treatment almost invariably involves phar-macotherapies that involve coagulation, with drugs ranging from aspirin to anticoagulants, both new and old. Nevertheless, the focus on pharmacotherapy modulation of coagulation processes tends to overlook some basic pathophys...
متن کاملThrombosis and Hemostasis
We recently demonstrated that blockade of the platelet adhesion receptor glycoprotein (GP) Ib protects mice from ischemic stroke. Although von Willebrand factor (VWF) is the major ligand for GPIb , GPIb can engage other counterreceptors on endothelial cells, platelets, and leukocytes (eg, Mac-1 or P-selectin) potentially involved in stroke outcome. To further analyze whether VWF is of particula...
متن کاملThrombosis and Hemostasis
1Inserm, Unite 872, Centre de recherche des Cordeliers, Paris, France; 2Université Pierre et Marie Curie-Paris 6, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; 3Université Paris Descartes, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; and 4Department of Drug Discovery and Development, Italian Institute of Technology, Geno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2007
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000257138.15250.48