Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
نویسندگان
چکیده
منابع مشابه
Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.
The high affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored cellular receptor (uPAR) promotes plasminogen activation and the efficient generation of pericellular proteolytic activity. We demonstrate here that expression of the tetraspanin CD82/KAI1 (a tumor metastasis suppressor) leads to a profound effect on uPAR function. Pericellular plasm...
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The 'metastasis suppressor' CD82/KAI-1, a member of the tetraspanin superfamily of transmembrane proteins, is widely distributed in normal tissues [1], and has been shown to be suppressed in the advanced stages of various epithelial malignancies [2-6]. Although the physiological relevance of this change is unknown, in vitro data show that ectopically expressed CD82/KAI-1 can suppress tumor cell...
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Cell-cell adhesion is mediated by interaction of a number of protein complexes residing on the cell plasma membranes. Disruption of these complexes affects structural and functional integrity of tissues. It has been hypothesized that a membrane protein tetraspanin CD82, a known metastasis suppressor, may play a role in regulating cell adhesion. Two proteins of interest (PG and Dsg2) have been f...
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We have previously shown that CD82, a transmembrane protein of the tetraspanin superfamily is associated with EGFR and has a negative effect on EGF-induced signalling (Odintsova, E., Sugiura, T. and Berditchevski, F. (2000) Curr. Biol. 10, 1009-1012). Here we demonstrate that CD82 specifically attenuates ligand-induced dimerization of EGFR. The recombinant soluble large extracellular loop of CD...
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T-cell activation is initiated by the concerted engagement of the T-cell receptor and different co-stimulatory molecules, and requires cytoskeleton-dependent membrane dynamics. Here, we have studied the relationships between tetraspanins, cytoskeleton and raft microdomains, and their relevance in T-cell signaling. Localization studies and density-gradient flotation experiments indicate that par...
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ژورنال
عنوان ژورنال: Bone Reports
سال: 2019
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2019.100196