Regulation of class switch recombination and somatic mutation by AID phosphorylation
نویسندگان
چکیده
منابع مشابه
Regulation of class switch recombination and somatic mutation by AID phosphorylation
Activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. However, AID can also produce off-target DNA damage,...
متن کاملThe Function of AID in Somatic Mutation and Class Switch Recombination
The immune system has evolved specific mechanisms to combat a potentially limitless number of foreign pathogens using a limited arsenal of Ig genes. To diversify the coding potential of the Ig genes, B cells undergo several processes of regulated genetic alterations. Early in their development, B cells in the bone marrow undergo V(D)J recombination to juxtapose variable region V, D, and J segme...
متن کاملIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.
Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch (S) regions and Ig variable region (V) exons. AID that is phosphorylated on serine residue 38 interacts with replication protein A (R...
متن کاملQuantitative Regulation of Class Switch Recombination by Switch Region Transcription
The isotype specificity of immunoglobulin (Ig) class switching is regulated by a cytokine which induces transcription of a specific switch (S) region, giving rise to so-called germline transcripts. Although previous studies have demonstrated that germline transcription of an S region is required for class switch recombination (CSR) of that particular S region, it has not been shown whether the ...
متن کاملChronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation.
In B cells, somatic hypermutation (SHM) and class switch recombination (CSR) depend on the activation-induced cytidine deaminase (AID) gene product, although the precise mode of action of AID remains unknown. Because some chronic lymphocytic leukemia (CLL) B cells can undergo CSR without SHM, it constitutes a useful model to dissect AID function. In this work, we have studied AID expression, th...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2008
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20081319