Regulating trained immunity with nanomedicine

Trained immunity refers to a hyperresponsive functional state of the innate immune system, which is induced by certain stimuli, such as infections or vaccination. plays key part in variety diseases, including cancer and inflammation, regulated through epigenetic metabolic reprogramming haematopoietic stem progenitor cells bone marrow, giving rise hyperactive myeloid cells. Nanomaterials inherently interact with phagocytic are thus ideal platforms regulate trained immunity. In this Review, we discuss pathways investigate nanomedicine strategies therapeutically Nanomedicine can be applied not only induce treat enhance resistance infections, but also manage hyperinflammation maladaptive clinical scenarios. We conclude an outlook future possibilities some remaining challenges for approaches regulation. form nonspecific memory, harboured within system. This Review discusses treatment various conditions, cancer, inflammation infection.