منابع مشابه
INK4a-ARF alterations in liver cell adenoma.
BACKGROUND The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), whose functions are inactivated in many human cancers. AIMS To evaluate p14(ARF) and p16(INK4a) alterations in liver cell adenoma. METHODS After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivati...
متن کاملSurgical strategies for liver cell adenoma
Liver cell adenomas (LCA) are benign tumors that occur primarily in women with a history of oral contraceptive use. While rare, LCA are clinically important because of their propensity for sudden, unpredictable hemorhage or malignant transformation. Differentiation from focal nodular hyperplasia or hepatocellular carcinoma may be difficult even with sophisticated imaging modalities. Current man...
متن کاملLIVER DISEASE INK4a-ARF alterations in liver cell adenoma
Background: The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16 and p14, whose functions are inactivated in many human cancers. Aims: To evaluate p14 and p16 alterations in liver cell adenoma. Methods: After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivation by DNA sequence analys...
متن کاملRegarding 'Liver cell adenoma and liver cell adenomatosis' by Ludger Barthelmes and Iain S. Tait.
We read with great interest the recent article by Barthelmes and Tait (HPB 2005;7:186 /196). The impact of the diagnosis ‘liver cell adenoma’ on the life of a young female patient is enormous. Conservative management of liver cell adenoma frequently implies cessation of oral contraceptives, regular follow-up including radiological imaging, and negative advice regarding pregnancy. Surgical treat...
متن کاملSystemic AA amyloidosis induced by liver cell adenoma.
Systemic AA amyloidosis is a rare complication of benign tumours. This report describes a patient with hepatocellular adenoma associated with reactive AA amyloidosis. He had a nephrotic syndrome with deteriorating renal function and an increase of serum concentrations of acute phase proteins, mainly C-reactive protein. Resection of the tumour was followed by improvement in renal function and a ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1982
ISSN: 0016-5085
DOI: 10.1016/0016-5085(82)90327-4