Registry-based studies: What they can tell us, and what they cannot

Cross-Cultural Piagetian Studies: What Can They Tell Us?/

Bone allografts: What they can offer and what they cannot.

Bone allografts can be used in any kind of surgery involving bone from minor defects to major bone loss after tumour resection. This review describes the various types of bone grafts and the current knowledge on bone allografts, from procurement and preparation to implantation. The surgical conditions for optimising the incorporation of bone are outlined, and surgeon expectations from a bone al...

Self-reported work-limitation data: what they can and cannot tell us.

Despite their widespread use in the literature, the Current Population Survey (CPS) and similar surveys have come under attack of late. We put the criticisms in perspective by systematically examining what the CPS data can and cannot be used for in disability research compared to the National Health Interview Survey. On the basis of our findings, we argue (1) that the CPS can be used to monitor...

Atypical centromeres in plants—what they can tell us

The centromere, visible as the primary constriction of condensed metaphase chromosomes, is a defined chromosomal locus essential for genome stability. It mediates transient assembly of a multi-protein complex, the kinetochore, which enables interaction with spindle fibers and thus faithful segregation of the genetic information during nuclear divisions. Centromeric DNA varies in extent and sequ...

Descriptive studies: what they can and cannot do.

Descriptive studies often represent the first scientific toe in the water in new areas of inquiry. A fundamental element of descriptive reporting is a clear, specific, and measurable definition of the disease or condition in question. Like newspapers, good descriptive reporting answers the five basic W questions: who, what, why, when, where. and a sixth: so what? Case reports, case-series repor...