Regeneration of dopaminergic neurons in goldfish retina
نویسندگان
چکیده
منابع مشابه
Regeneration of dopaminergic neurons in goldfish retina.
The conditions necessary to trigger regeneration of dopaminergic neurons were investigated in the goldfish retina. Intraocular injection of 6-hydroxydopamine (6-OHDA) was used to destroy dopaminergic neurons, and neuronal regeneration was monitored by injections of the thymidine analog bromodeoxyuridine (BUdR). Regenerated dopaminergic neurons, (identified by double-labeling with anti-tyrosine ...
متن کاملContinued search for the cellular signals that regulate regeneration of dopaminergic neurons in goldfish retina.
Intraocular injections of low doses (0.7-1.4 mM estimated intraocular concentration) of 6-hydroxydopamine (6OHDA) selectively destroy dopaminergic neurons in the inner nuclear layer (INL) of goldfish retina, and they never regenerate. However, injection of a higher dose of 6OHDA (2.9 mM) destroys > 30% (but not all) of the cells in both the INL and the outer nuclear layer (ONL), but within 3 we...
متن کاملSelective regeneration of photoreceptors in goldfish retina.
Previous work has shown that the neural retina in adult goldfish can regenerate. Following retinal damage elicited by surgical or cytotoxic lesions, missing neurons are replaced by foci of proliferating neuroepithelial cells, which previous studies have suggested are derived from rod precursors. In the intact retina, rod precursors proliferate but produce only new rods. The regenerative respons...
متن کاملLocal regeneration in the retina of the goldfish.
We have studied regeneration of the retina in the goldfish as a model of regenerative neurogenesis in the central nervous system. Using a transscleral surgical approach, we excised small patches of retina that were replaced over several weeks by regeneration. Lesioned retinas from three groups of animals were studied to characterize, respectively, the qualitative changes of the retina and surro...
متن کاملRNA metabolism in the goldfish retina during optic nerve regeneration.
In goldfish, regeneration of the optic nerve following axotomy is accompanied by changes in retinal RNA metabolism. Approximately 4 days after unilateral optic nerve crush, there is an increased uptake of 'H-labeled precursors of RNA into cells of the retina as well as an increase in labeling of total retinal RNA following incubation for 3 4 h in uitro. Subfractionation indicates that the resul...
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ژورنال
عنوان ژورنال: Development
سال: 1992
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.114.4.913