Regarding the Overestimation of Serum κ Free Light Chains
نویسندگان
چکیده
منابع مشابه
Regarding the overestimation of serum κ free light chains.
Employment or Leadership: None declared. Consultant or Advisory Role: F.C. Wu, Organon International, Bayer Schering Pharma, Eli Lilly, Proctor & Gamble, Pierre Fabre Medicaments, Ferring Pharmaceuticals, TAP Pharmaceuticals, Ardana Bioscience, and GlaxoSmithKline. Stock Ownership: None declared. Honoraria: F.C. Wu, Organon International, Bayer Schering Pharma, Lilly ICOS, Ardana Bioscience, an...
متن کاملQuantitation of serum free light chains.
under usual artificial light conditions, and storage of unproc-essed whole blood without antico-agulants at room temperature on the bench. Additionally, we tested the effect of multiple freeze-thaw cycles. 25(OH)–vitamin D 3 measurements were performed on a Cobas E601 an-alyzer (Roche), using the vitamin D 3 (25-OH) assay as recommended by the manufacturer. Samples from each storage experiment ...
متن کاملMeasurement of immunoglobulin free light chains in serum.
but the active/latent isoform proportions were similar (Fig. 1A). Platelet aggregation during clotting (6) may have caused these differences. MMP expression was lower in K 2 E plasma than in LH plasma [14 (3) vs 25 (4) g/L; P Ͻ0.05; Fig. 1A, lane 4 vs lane 5]. The concentrations of MMP-9 forms decreased significantly with increasing amounts of K 2 E during PB collection, whereas MMP-2 was incr...
متن کاملIdentification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine.
BACKGROUND The diagnosis of systemic immunoglobulin light-chain (AL) amyloidosis requires demonstration of amyloid deposits in a tissue biopsy and amyloidogenic monoclonal light chains. The optimal strategy to identify the amyloidogenic clone has not been established. We prospectively assessed the diagnostic sensitivity of the serum free light chain (FLC) kappa/lambda ratio, a commercial serum ...
متن کاملComparison of free κ and λ light chain immunoassays and total (bound and free) κ and λ light chain immunoassays.
Comparison of free κ and λ light chain immunoassays and total (bound and free) κ and λ light chain immunoassays To the editor: We read, with interest, the article by Dr. Zamora-Ortiz, et al. Poor performance of the total kappa/ lambda light chain quantification in the diagnosis and follow-up of patients with multiple myeloma on the comparison of the total serum light chain assay (sLC), SPE and ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2011
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2010.158774