منابع مشابه
Project of Refurbishment of the Gilda Beamline at the Esrf
This document presents the refurbishment project for GILDA, the Italian CRG beamline at the ESRF. After a short introduction to the beamline and its achievements in the last years, the base ideas and concepts driving the design are exposed whereas a more detailed technical description of the new instrument is given in a further section. An analysis of the costs and a schedule for the implementa...
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The spindle checkpoint acts as a mitotic surveillance system, monitoring interactions between kinetochores and spindle microtubules and ensuring high-fidelity chromosome segregation [1-3]. The checkpoint is activated by unattached kinetochores, and Mps1 kinase phosphorylates KNL1 on conserved MELT motifs to generate a binding site for the Bub3-Bub1 complex [4-7]. This leads to dynamic kinetocho...
متن کاملTPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.
Recently, we isolated from bovine brain a protein, TPPP/p25 and identified as p25, a brain-specific protein that induced aberrant tubulin assemblies. The primary sequence of this protein differs from that of other proteins identified so far; however, it shows high homology with p25-like hypothetical proteins sought via blast. Here, we characterized the binding of TPPP/p25 to tubulin by means of...
متن کاملStatus of SST-1 Refurbishment
Steady State Tokamak (SST-1) refurbishment at the Institute for Plasma Research has been recognized and accepted as a Mission activity since Jan 2009 with an ultimate objective of producing the first plasma by the end of 2011. Under the SST-1 Mission mandate, several refurbishment activities have been initiated and pursued vigorously on various sub-systems of SST-1. Developing reliable designs ...
متن کاملVisualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells
The spindle checkpoint prevents errors in chromosome segregation by inhibiting anaphase onset until all chromosomes have aligned at the spindle equator through attachment of their sister kinetochores to microtubules from opposite spindle poles. A key checkpoint component is the mitotic arrest-deficient protein 2 (Mad2), which localizes to unattached kinetochores and inhibits activation of the a...
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ژورنال
عنوان ژورنال: Stankoinstrument
سال: 2019
ISSN: 2499-9407
DOI: 10.22184/24999407.2019.14.01.82.84