Reflections on STAT3, STAT5, and STAT6 as fat STATs.
نویسندگان
چکیده
منابع مشابه
Reflections on STAT3, STAT5, and STAT6 as fat STATs.
The current issue of the Proceedings contains an article entitled "Defective STAT signaling by the leptin receptor in diabetic mice" by Ghilardi et al. (1). The reported results suggest how leptin, the recently discovered weight control hormone (2), may signal cells through its cognate receptor by activation of STATs, proteins that serve the dual function of signal transducers and activators of...
متن کاملReciprocal effects of STAT5 and STAT3 in breast cancer.
Breast cancer is often associated with inappropriate activation of transcription factors involved in normal mammary development. Two related transcription factors, signal transducer and activator of transcription (STAT) 5 and STAT3, play important and distinct roles in mammary development and both can be activated in breast cancer. However, the relative contribution of these STATs to mammary tu...
متن کاملJaks and stats as therapeutic targets.
Cytokines have critical functions in regulating immune responses. A large number of these factors bind related receptors termed the Type I and Type II families of cytokine receptors. These receptors activate Janus kinases (Jaks) and Stat family of transcription factors. The essential and specific function of Jaks and Stats is particularly well illustrated by human and mouse mutations. The possi...
متن کاملA positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.
STAT3 and STAT5 are constitutively activated and nuclear in nasopharyngeal carcinoma (NPC) cells. In normal signaling, STATs are only transiently activated. To investigate whether Epstein-Barr virus (EBV), and in particular the protein LMP1, contributes to sustained STAT phosphorylation and activation in epithelial cells, we examined STAT activity in two sets of paired cell lines, HeLa, an EBV-...
متن کاملSelective activation of members of the signal transducers and activators of transcription family in prostate carcinoma.
PURPOSE Cytokines, hormones and growth factors use signal transducers and activators of transcription (STAT) signaling pathways to control various biological responses, including development, differentiation, cell proliferation and survival. Constitutive activation of STATs has been found in a wide variety of human tumors. In this study we examined the activity of STATs in primary human prostat...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.13.6221