Reflections on radiogenomics and oncologic radiomics

Radiomics and radiogenomics for precision radiotherapy

Imaging plays an important role in the diagnosis and staging of cancer, as well as in radiation treatment planning and evaluation of therapeutic response. Recently, there has been significant interest in extracting quantitative information from clinical standard-of-care images, i.e. radiomics, in order to provide a more comprehensive characterization of image phenotypes of the tumor. A number o...

Radiogenomics and Radioproteomics

Recent whole-genome sequencing efforts have expanded on the traditional histologically-driven subtypes to further stratify cases according to the presence/absence of specific somatic mutations in oncogenes integral to cancer initiation, progression and metastasis. The development of ‘targeted therapeutics’ intended to specifically short-circuit regulatory pathways has led to the successful deve...

Radiogenomic Analysis of Oncological Data: A Technical Survey

In the last few years, biomedical research has been boosted by the technological development of analytical instrumentation generating a large volume of data. Such information has increased in complexity from basic (i.e., blood samples) to extensive sets encompassing many aspects of a subject phenotype, and now rapidly extending into genetic and, more recently, radiomic information. Radiogenomic...

Radiomics and Deep Learning

Applications and limitations of radiomics.

Radiomics is an emerging field in quantitative imaging that uses advanced imaging features to objectively and quantitatively describe tumour phenotypes. Radiomic features have recently drawn considerable interest due to its potential predictive power for treatment outcomes and cancer genetics, which may have important applications in personalized medicine. In this technical review, we describe ...