Reflections on a 40-year career in drug design and discovery
نویسندگان
چکیده
In this article, I reflect on a 40-year career in drug discovery at Bristol Myers Squibb that encompassed the cardiovascular, central nervous system and antiviral therapeutic areas. share scientific observations made design optimization of cAMP phosphodiesterase inhibitors, prostacyclin partial agonists, maxi-K ion channel openers, influenza respiratory syncytial virus hepatitis C NS3/4A proteas, NS5A replication complex NS5B polymerase inhibitors HIV-1 attachment maturation.
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2023
ISSN: ['1554-8120', '1054-2523']
DOI: https://doi.org/10.1007/s00044-023-03070-6