Reduction of Acid Amides to Amines with Sodium Borohydride
نویسندگان
چکیده
منابع مشابه
The reduction of cozymase by sodium borohydride.
Cozymase (diphosphopyridine nucleotide, DPN) has been assayed by a variety of biochemical and chemical methods (1). Among the simplest procedures has been the determination of the light absorption of reduced DPN at 340 rnp after reduction by sodium hydrosulfite. Since special precautions are required to remove completely the excess reducing agent which absorbs in this region, it appeared advant...
متن کاملSelective reduction of amides to amines by boronic acid catalyzed hydrosilylation.
Not a 'B'ore! Benzothiophene-based boronic acids catalyze the reduction of tertiary, secondary, and primary amides in the presence of a hydrosilane. The reaction demonstrates good functional-group tolerance.
متن کاملHomogeneous catalytic hydrogenation of amides to amines.
Hydrogenation of amides in the presence of [Ru(acac)3] (acacH=2,4-pentanedione), triphos [1,1,1-tris- (diphenylphosphinomethyl)ethane] and methanesulfonic acid (MSA) produces secondary and tertiary amines with selectivities as high as 93% provided that there is at least one aromatic ring on N. The system is also active for the synthesis of primary amines. In an attempt to probe the role of MSA ...
متن کاملReduction of Chlorophyllides, Chlorophylls and Chlorophyll Derivatives by Sodium Borohydride.
Sodium borohydride is a well known reducing agent. In methanol at room temperature formyl and keto groups are readily reduced to alcohol groups, while ester and carboxyl groups, carbon-carbon and carbon-nitrogen double bonds are only reduced with difficulty (2, 17). Of the groups present in chlorophyll b the C3 formyl and the C9 keto groups should be amenable to reduction, while the C2 vinyl an...
متن کاملThe Ninhydrin Reaction with Amines and Amides
1 Harding, V. J., and Warneford, F. H. S., J. Biol. Chem., 1916, xxv, 319. 2 Dakin, H. D., and Dudley, H. W., J. Biol. Chem., 1913, xv, 127. 3 Neuberg, C., Biochem. Z., 1913, lvi, 500. 4 Ruhemann, S., J. Chem. Sot. 1910, xcvii, 2026. 5 In this and the preceding paper triketohydrindene hydrate has sometimes been written as the triketone for the sake of simplicity in explaining the decompositions...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1965
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.13.394