Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients
نویسندگان
چکیده
منابع مشابه
Reduced task-related functional connectivity during a set-shifting task in unmedicated Parkinson’s disease patients
Patients with Parkinson's disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine depletion leads to a sub-optimal functional connectivity between task-related brain areas and consequently results in impaired task-performance. In this study, we aimed to examine this hyp...
متن کاملDopamine depletion impairs frontostriatal functional connectivity during a set-shifting task.
We investigated the effect of transient dopamine depletion on functional connectivity during performance of the Wisconsin Card Sorting Task. Functional magnetic resonance imaging data were analyzed as a psychophysiological interaction, a statistical method used to identify functional connectivity during experimental manipulations. Nineteen healthy subjects were scanned, double blind, on 2 separ...
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Autism spectrum disorder (ASD) is a characterized by deficits in social cognition and executive function. An area of particular difficulty for children with ASD is cognitive flexibility, such as the ability to shift between attentional or response sets. The biological basis of such deficits remains poorly understood, although atypical development of structural and functional brain connectivity ...
متن کاملReduced neural connectivity but increased task-related activity during working memory in de novo Parkinson patients.
OBJECTIVE Patients with Parkinson's disease (PD) often suffer from impairments in executive functions, such as working memory deficits. It is widely held that dopamine depletion in the striatum contributes to these impairments through decreased activity and connectivity between task-related brain networks. We investigated this hypothesis by studying task-related network activity and connectivit...
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Patients with Parkinson's disease (PD) often suffer from impairments in executive functions, such as mental rigidity, which can be measured as impaired set-shifting. Previous studies have shown that set-shifting deficits in patients with PD result from hypo-excitation of the caudate nucleus and lateral prefrontal cortices. The results of these studies may have been influenced by the inclusion o...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2016
ISSN: 1471-2202
DOI: 10.1186/s12868-016-0254-y