Reduced Prepulse Inhibition as a Biomarker of Schizophrenia
نویسندگان
چکیده
منابع مشابه
Reduced Prepulse Inhibition as a Biomarker of Schizophrenia
The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is...
متن کاملLinking Stress and Schizophrenia: A Focus on Prepulse Inhibition
Schizophrenia affects about 0.5-1.0% of people worldwide, occurring roughly equally in both men and women. The exact causes of schizophrenia are not fully understood, although the consensus of current research is that schizophrenia is a developmental disorder, caused by a genetic liability interacting with environmental and psychosocial stress. However, the possible neurobiological mechanisms u...
متن کاملPrepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings.
BACKGROUND Deficits in schizophrenia patients and their first-degree relatives have been reported in prepulse inhibition (PPI), a phenomenon that measures an early stage of information processing (sensorimotor gating). It is less clear whether these information processing deficits extend to prepulse facilitation (PPF), which measures a later stage of generalized alerting or orienting. METHODS...
متن کاملEffective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients.
BACKGROUND The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuroleptic drug treatment as is suggested by animal research. METHODS Prepulse ...
متن کاملReduced prepulse inhibition is associated with increased hypnotizability.
Hypnosis involves the manipulation of conscious attentional discrimination. The prepulse inhibition (PPI) paradigm assesses primary unconscious information processing. We investigated the correlation between hypnotizability and PPI of the startle reflex. Forty-eight healthy subjects were evaluated with the Stanford Hypnotic Susceptibility Scale, Form C (SHSS:C) and acoustic PPI. Subjects were d...
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ژورنال
عنوان ژورنال: Frontiers in Behavioral Neuroscience
سال: 2016
ISSN: 1662-5153
DOI: 10.3389/fnbeh.2016.00202