Reduced naïve CD 8 + T ‐cell priming efficacy in elderly adults

Reduced naïve CD8(+) T-cell priming efficacy in elderly adults.

Aging is associated with impaired vaccine efficacy and increased susceptibility to infectious and malignant diseases. CD8(+) T-cells are key players in the immune response against pathogens and tumors. In aged mice, the dwindling naïve CD8(+) T-cell compartment is thought to compromise the induction of de novo immune responses, but no experimental evidence is yet available in humans. Here, we u...

CD 40 - independent Pathways of T Cell Help for Priming of CD 8 1 Cytotoxic T Lymphocytes

In many cases, induction of CD8 1 CTL responses requires CD4 1 T cell help. Recently, it has been shown that a dominant pathway of CD4 1 help is via antigen-presenting cell (APC) activation through engagement of CD40 by CD40 ligand on CD4 1 T cells. To further study this three cell interaction, we established an in vitro system using dendritic cells (DCs) as APCs and influenza hemagglutinin (HA...

Priming in the Mouse Infection Model Outer Protein P Inhibits CD 8 T Cell

Programming for CD 8 T Cell Memory

IFN - T Cell Subsets to Express IL - 18 Receptor − CD 8 − , and CD 4 + , CD 8 + Differential Capacities of CD