Reduced expressions of connexin 43 and VEGF in the first-trimester tissues from women with recurrent pregnancy loss

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Reduced expressions of connexin 43 and VEGF in the first-trimester tissues from women with recurrent pregnancy loss

BACKGROUND Approximately 45-50 % of the recurrent pregnancy loss (RPL) remain(s) unexplained that challenges its clinical management. Formation and development of placenta as well as angiogenesis are critical for successful pregnancy. Vascular endothelial growth factor (VEGF) and connexin 43 (Cx43) play important roles in angiogenesis and placenta development and aberration of these have been l...

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Background/objective: Studies of the decidual leukocyte populations in women suffering from spontaneous early pregnancy loss may provide insight into immunpathological aspects and even cast light on the etiology of recurrent spontaneous abortion.Methods: In order to clarify the immunological role of endometrial leukocytes in repetitive abortion of unknown etiology, a comparative analysis of phe...

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Prevalence of hypothyroidism in recurrent pregnancy loss in first trimester.

AIM To determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the Indian population. SETTINGS AND DESIGN The study included 163 non-pregnant women with recurrent pregnancy loss in a gestational age up to <or=12 weeks verified by a pregnancy test or ultrasonography, and a total of 170 age matched women with at least one successful pregnancy and n...

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Endometrial Scratching in Women with Recurrent First Trimester Pregnancy Loss: A Randomized Controlled Trial

Objective: to assess the role of endometrial scratching prior to ovulation induction to improve live birth rate in recurrent first trimester pregnancy loss. Methods: This randomized controlled trial included 126 patients with recurrent first trimester spontaneous miscarriage with no obvious cause who were assigned into two groups; the study group (n=62) who underwent endometrial scratching once...

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The Effect of Lymphocyte Therapy on the Expression of MicroRNAs in Women with Recurrent Pregnancy Loss

Background: Recurrent Pregnancy Loss (RPL) is 2 or more recurrent miscarriages before the twentieth week, which occurs in 2-5% of women of gestational age. Considering the significant role of the immune system in the process of a successful pregnancy, it is expected that in addition to the common and well-known treatments used for patients with recurrent miscarriage to date, intracutaneous lymp...

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ژورنال

عنوان ژورنال: Reproductive Biology and Endocrinology

سال: 2016

ISSN: 1477-7827

DOI: 10.1186/s12958-016-0179-4