Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

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PTK2 and PTPN11 expression in myelodysplastic syndromes

OBJECTIVE The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS Protein tyrosine kinase 2 and tyrosine phospha...

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The myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders characterized by dysplastic and ineffective hematopoiesis and a varying risk of transformation to acute leukemia. Although the natural history of these syndromes is variable, several factors appear to be of prognostic importance, including the French-American-British classification, the karyotype, in vi...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2015

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1516394112