Redox Sensitive MR Contrast Agent
نویسندگان
چکیده
منابع مشابه
Recent Advances in PET-MR Hybrid contrast agent
Introduction: All of the Imaging modalities have advantages and disadvantages alone. So if we want to have the best and perfect image, combining these modalities produces something we desired. PET-MR images consist of morphologic and metabolic data. MRI and PET provide high spatial and contrast resolution and high sensitivity and molecular information respectively. Hybrid PET-...
متن کاملInhaled oxygen: a brain MR contrast agent?
Oxygen inhalation led to subtle but readily detectable changes on T2*-weighted images with a conventional MR imager at 1.5 T. We attribute the increase in local signal intensity to changes in blood oxygenation, in particular to a net conversion of deoxyhemoglobin to oxyhemoglobin.
متن کاملProbing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents.
Nitroxide radicals are paramagnetic contrast agents, used in magnetic resonance imaging (MRI), that also exert antioxidant effects. Participating in cellular redox reactions, they lose their ability to provide contrast as a function of time after administration. In this study, the rate of contrast loss was correlated to the reducing power of the tissue or the "redox status." The preferential re...
متن کاملA multimeric MR-optical contrast agent for multimodal imaging.
We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applica...
متن کاملImaging hypoxia using a nitroimidazole based T1 MR contrast agent
Introduction: Hypoxic regions in tumors are known to affect radiation sensitivity and promote development of metastases [1]. Noninvasive imaging based methods such as MRI are particularly suitable for longitudinal measurements and generation of three-dimensional spatial maps of tumor hypoxia [2]. An MRI method that could differentiate hypoxic versus normoxic tissues without relying on washout m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.lb489