Redox regulation of the insulin signalling pathway
نویسندگان
چکیده
منابع مشابه
The insulin signalling pathway
A significant stress faced by all animals is the unpredictable cycle of feeding and then starvation that ensues between meals. Humans solve this problem by storing nutrients in forms that can be used as energy sources during periods of fasting. The driving force that regulates this process is insulin, a hormone released by the β-pancreatic islet cells in response to elevated levels of nutrients...
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Insulin-degrading enzyme (IDE) is a thiol sensitive peptidase that degrades insulin and amyloid β, and has been linked to type 2 diabetes mellitus and Alzheimer's disease. We examined the thiol sensitivity of IDE using S-nitrosoglutathione, reduced glutathione, and oxidized glutathione to distinguish the effects of nitric oxide from that of the redox state. The in vitro activity of IDE was stud...
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The insulin signaling pathway propagates a signal from receptors in the cell membrane to the nucleus via numerous molecules some of which are transported through the cell in a partially stochastic way. These different molecular species interact and eventually regulate the activity of the transcription factor FOXO, which is partly responsible for inhibiting the growth of organs. It is postulated...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2021
ISSN: 2213-2317
DOI: 10.1016/j.redox.2021.101964