Redirecting the specificity of ubiquitination by modifying ubiquitin-conjugating enzymes.
نویسندگان
چکیده
منابع مشابه
Redirecting the specificity of ubiquitination by modifying ubiquitin-conjugating enzymes.
Depletion of specific cellular proteins is a powerful tool in biological research and has many medical and agricultural benefits. In contrast to genetic methods currently available to attenuate protein levels, we describe an alternative approach that redirects the ubiquitin-dependent proteolytic pathway to facilitate specific proteolytic removal. Degradation via the ubiquitin pathway requires t...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.20.9117