Redefining cancer of unknown primary: Is precision medicine really shifting the paradigm?
نویسندگان
چکیده
The concept of Cancer Unknown Primary (CUP) has evolved with the advent medical oncology. CUP can be difficult to diagnose and represents 2 5% new cancers, therefore not exceptionally rare. Within CUPs identified a subset favourable prognosis tumours, however vast majority patients belongs poor group.CUP features significant oncological challenges, such as unravelling biological transversal issues, most importantly, improving patient’s outcomes. In that regard, patients’ outcomes regrettably showed minimal improvement for decades remains cancer group very prognosis.The biology two main hypotheses. One is subgroup given primary cancer, where present but cannot seen due its small size. other, “true” hypothesis, states share make them specific entity, whatever their tissue origin. A true signature yet been described, chromosomal instability hallmark group.Precision oncology, despite achieving identifying putative origin CUP, so far failed globally improve patients. Targeting molecular pathways based on analysis in management under investigation. Immunotherapy shown ground-breaking results, date. Accrual also crucial issue trials.Herein we review history, remaining questions biology, approaches oncology management, order draw perspectives enormous challenge patient
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ژورنال
عنوان ژورنال: Cancer Treatment Reviews
سال: 2021
ISSN: ['1532-1967', '0305-7372']
DOI: https://doi.org/10.1016/j.ctrv.2021.102204